Ribosomal protein S6



Ribosomal protein S6 (RPS6) is one of the 22 proteins which belong to the small subunit of the bacterial ribosome. It has a role in regulating translation of RNAs that contain the 5' terminal sequence. It is regulated by ribosomal S6 kinase. The images at the left and at the right correspond to one representative RPS6, i.e. the crystal structure of Ribosomal protein S6 from Thermus thermophilus (2zm6, chain F).

3D Structures of Ribosomal protein S6
Update June 2011

RPS6
2kjv – TtRPS6 – NMR - Thermus thermophilus

2kjw – TtRPS6 (mutant)– NMR

2bvz, 1ris – TtRPS6

2bxj, 1cqm, 1cqn, 1qjh, 1lou - TtRPS6 (mutant)

2j5a – RPS6 – Aquifex aeolicus

1vmb – RPS6 – Thermotoga maritima

3r3t – RPS6 – Bacillus anthracis

S5 in small ribosomal subunit
2zm6, 1n36, 1j5e, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4, 3oto - TtRPS6 in 30S ribosomal subunit+THX+16S RRNA

2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS6 in 30S ribosomal subunit+16S RRNA+RNA fragment

3kc4 – EcRPS6 in 30S ribosomal subunit - Escherichia coli

3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 1oaq, 3oar, 3ofa, 3ofb, 2ofo, 3ofp, 3ofx, 3ofy, 3or9, 3ora - EcRPS6 in 30S ribosomal subunit+16S RRNA

1i94, 1fka - TtRPS6 in 30S ribosomal subunit+16S RRNA

1p87, 1p6g - EcRPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM

3bbn - RPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach

S6 in small + large ribosomal subunit
1ml5 - EcRPS6 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM

S6 in small ribosomal subunit+ chain release factor
3mr8, 3ms0 – TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA

3d5a, 3d5c - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA

2b64 - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1

2b9m - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2

2x9r, 2x9t, 2wh1, 2wh3 - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA

3f1e, 3f1g - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA

S6 in small ribosomal subunit+tRNA+mRNA
2hgi - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet

2hgp - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA

2i2p, 2i2u - EcRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA

2hgr - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA

1yl4 – TtRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator

1pns - EcRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA

1xnq, 1xnr - TtRPS6 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA

S6 in small ribosomal subunit+A-site tRNA
2uxd, 2uxc - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA

1n32, 1n33 - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA

1n34 - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA

1xmo, 1xmq - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA

2uxb - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA

S6 in small ribosomal subunit+P-site tRNA
3i8g - TtRPS6 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA

3i8h, 3i9b, 3i9d - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA

1ibk - TtRPS6 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA

2wwl - EcRPS6 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli

3i1q - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA

3i1s, 3i1z, 3i21 - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA

S6 in small ribosomal subunit+A-site tRNA+P-site tRNA
1ibl, 1ibm - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA

S6 in small ribosomal subunit+P-site tRNA+E-site tRNA
2ow8 - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA

2b9o - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA

2qnh - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA

2wdg, 2wdh, 2wdk, 2wdm - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe

S6 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA
2gy9, 2gyb - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM

1jgo, 1jgp, 1jgq, 1gix - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA

3e1a, 3e1c - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA

S6 in small ribosomal subunit + antibiotics
1i95, 1i97, 2hhh, 2f4v, 3knn - TtRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic

1hnw, 1hnx, 1hnz, 1fjg - TtRPS6 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic

2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow,  2qoy,  2qp0,  2z4k, 2z4m, 3oaq, 3ofo - EcRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic

2j00, 2j02 - TtRPS6 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA

3knj, 3knh - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin

3knl, 3knm - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin

S6 in small ribosomal subunit + ribosome recycling factor
2qbd, 2qbf - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor

3r8n, 3r8o – EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA

2qbh, 2qbj - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin

2v46, 2v48 - TtRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet

S6 in small ribosomal subunit + elongation factor
2wri, 2wrk, 2xsy, 2xuy - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G

2wrn, 2wrq - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4

3fic - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A

3izv – EcRPS6 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU

3izw – EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU

2y0u, 2y0w, 2y0y, 2y10, 2y12, 2y14, 2y16, 2y18 - TtRPS6 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+elongation factor TU

3fih - EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU

3huw, 3huy - TtRPS6 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P

2xqd – TtRPS6 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B

S6 in small ribosomal subunit + translation initiation factor
1i96 - TtRPS6 in 30S ribosomal subunit+THX+IF3+16S RRNA

1hr0 - TtRPS6 in 30S ribosomal subunit+THX+IF+16S RRNA

S6 in small ribosomal subunit + various proteins
3kiq, 3kis, 3kiu, 3kix - TtRPS6 in 30S ribosomal subunit+toxin RelE+16S RRNA

1voq, 1vos, 1vov, 1vox, 1voz - EcRPS6 in 30S ribosomal subunit+protein Y+16S RRNA

3iy8 – EcRPS6+EcRPS5+EcRPS8+EcRPS9+EcRPS11+EcRPS12+EcRPS15+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae small subunit

2xfz, 2xg1 – TtRPS6 in 30S ribosomal subunit+colicin E3+E-site tRNA+mRNA+16S RRNA

3j00 – EcRPS6 + 16S RRNA + FTSQ + apolipoprotein A-I

S6 in part of small ribosomal subunit
1qd7 – TtRPS6+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment

1g1x - TtRPS6+TtRPS15+TtRPS18+16S RRNA fragment